The umbilical cord connects the foetus to the womb during pregnancy and is the essential conduit between mother and child. It is through the umbilical cord that nutrients and other factors flow to nourish the growing foetus.
The umbilical cord is also a rich source of stem cells. Stem cells are basic cells that can morph into a variety of specialised cells. For example, cord blood stem cells (also called haematopoietic stem cells) can morph into red blood cells as well as white blood cells.
Cord blood stem cells Differentiated into other blood cells (Source: NIH)
You have banked Cord Lining Stem Cells and these come from the outer amniotic lining (also called the cord lining) of the umbilical cord. This umbilical cord lining is currently the largest known reservoir of stem cells in human beings, and is truly Nature’s Gift to all of us.
Cross Section of Human Umbilical Cord
Every patent application undergoes careful and rigorous examination before it is granted, and the process can take a long time depending on the country where the application was submitted.
Once granted, however, the Patent becomes an assurance that the technology is sound and unique, and can stand up to the most rigorous scientific scrutiny. It is quite usual that as more countries approve the Patent, other countries will also follow over time.
We at CellResearch Corporation are pleased to have the “freedom to operate” under global patents filed, and granted. We currently have patents granted for the United Kingdom, Hong Kong, South Africa, Vietnam, Indonesia, Taiwan, Singapore, New Zealand, Malaysia and Russia, Australia, Mexico and Israel. Our fundamental patent is also pending in India, China and the United States amongst other global territories. Our patents, filed, pending and granted cover both the isolation and cultivation of cord lining stem cells as well as uses of cells, it is vital for those wishing to collect, process and store cord lining stem cells to do so with our licensed partners. This is in order to ensure that the cells are able to be used for future transplantation.
Cord Lining Stem Cells are a very valuable resource with established uses now, and for the future - a stunning potential.
CellResearch Corporation spends a great deal of time and effort to establish research ties with other specialist research groups in prestigious centres around the world to accelerate and exploit the capabilities of Cord Lining Stem Cells.
Cord Lining Stem Cells and/or Umbilical Cord Stem Cells are harvested from cord tissue membrane (http://en.wikipedia.org/wiki/Cord_lining). They were discovered by CellResearch Corporation's Chief Scientific Officer, Associate Professor (Dr) Phan Toan Thang and Chief Medical Officer, Adjunct Professor (Dr) Ivor Lim in 2004. The technology is now patented in 17 major geographies with many more awaiting patent grant. The banking and storage of the cord tissue membrane and stem cells a.k.a. cord tissue banking have been exclusively licensed to the following preferred partners;
1. China Cord Blood Corporation (http://www.chinacordbloodcorp.com/) in association with CordLife Group Ltd
2. CordLife Group Ltd (http://www.cordlife.com/)
3. MekoStem (http://www.mekostem.com/en)
4. StemCyte USA (http://www.stemcyte.com/)
5. StemCyte Taiwan (http://www.stemcyte.com.tw/)
Process and Use
Cord tissue membrane and cord lining stem cells use a patented processing technique. Outside of the above preferred partners, cells obtained by other means or from other service providers cannot be guaranteed for future use which may include stem cell therapy or stem cell treatments. Moreover, Epithelial Stem Cells in their earliest Passage and in large quantities can only be harvested from very limited sources and to date, the cord tissue membrane looks to have the largest yield.
From a single umbilical cord, up to 6 billion Mesenchymal Stem Cells and 6 billion Epithelial Stem Cells can be harvested in its earliest Passage, which is a very important consideration in the regenerative and therapeutic application requirement. Multiple regenerative and therapeutic applications are currently being studied and cord tissue membrane and cord lining stem cells should be a tissue of choice to be stored at birth together with cord blood. Information on cord lining stem cell uses can be found on the various pages inside http://vwwv.globalcordregistry.com/
Global Cord Registry
The cord lining stem cell technology patented by CellResearch Corporation encompasses 1) The Idea of obtaining stem cells from mammalian umbilical cord lining membrane (stem cells isolated from the amniotic lining membrane of umbilical cord of all Mammals), 2) Isolation Techniques for both Epithelial and Mesenchymal stem cells from mammalian umbilical cord amniotic lining membrane, 3) Culture and Maintenance Media Formulations and 4) Storage / banking and therapeutic applications of Cord Lining stem cells.
This has allowed CellResearch Corporation to consider multiple aspects of the technology including ensuring that the correct processing techniques are practiced with our preferred partners so that the cells will have a potential usage in the future and not be stored inappropriately today which may become a hazard to the uses downstream.
All licensed cord storage with our preferred partners are registered in the Global Cord Registry. Licensed cords can be assured that the stored cords can be used in the future when the relevant regenerative and therapeutic applications become a reality. An illustration of how the Global Cord Registry can be beneficial is shown below.